Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Adra2c	rgd:2058	[ENCODES a protein that exhibits alpha-2A adrenergic receptor binding (ortholog); alpha2-adrenergic receptor activity (ortholog); epinephrine binding (ortholog); INVOLVED IN female pregnancy; negative regulation of uterine smooth muscle contraction; positive regulation of vasoconstriction; ASSOCIATED WITH Hyperalgesia; Neuralgia; Cardiomegaly (ortholog); FOUND IN axon; axon terminus; glutamatergic synapse; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 3H-1,2-dithiole-3-thione; ammonium chloride]
Adrb1	rgd:2059	[ENCODES a protein that exhibits beta1-adrenergic receptor activity; dopamine binding; drug binding; INVOLVED IN aging; apoptotic process; G protein-coupled receptor signaling pathway; PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH Anaphylaxis; congestive heart failure; Diabetes Mellitus, Experimental ; FOUND IN cytoplasm; intracellular membrane-bounded organelle; membrane; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 3',5'-cyclic AMP]
Lenep	rgd:69433	[INVOLVED IN multicellular organism development (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A]
Synj1	rgd:69434	[ENCODES a protein that exhibits EH domain binding; inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; INVOLVED IN brain development; positive regulation of gliogenesis; positive regulation of receptor-mediated endocytosis; PARTICIPATES IN altered clathrin-dependent synaptic vesicle endocytosis; clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Ciliary Motility Disorders (ortholog); early infantile epileptic encephalopathy 1 (ortholog); early infantile epileptic encephalopathy 53 (ortholog); FOUND IN clathrin coat of coated pit; cytoplasm; microtubule; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; acrylamide]
Tcam1	rgd:69435	[INVOLVED IN cell-cell adhesion (inferred)]
Synj2	rgd:69436	[ENCODES a protein that exhibits inositol-polyphosphate 5-phosphatase activity; PDZ domain binding; phosphatidylinositol monophosphate phosphatase activity; INVOLVED IN brain development; inositol phosphate dephosphorylation; intracellular distribution of mitochondria; PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN axon terminus; cytoplasm; cytoplasmic microtubule; INTERACTS WITH 1-naphthyl isothiocyanate; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil]
Pick1	rgd:69437	[ENCODES a protein that exhibits actin filament binding; Arp2/3 complex binding; cytoskeletal protein binding; INVOLVED IN cellular response to decreased oxygen levels; cellular response to glucose starvation; dendritic spine maintenance; PARTICIPATES IN protein kinase C (PKC) signaling pathway; ASSOCIATED WITH amphetamine abuse (ortholog); substance-induced psychosis (ortholog); FOUND IN dendrite; glutamatergic synapse; neuron projection; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-nitropropanoic acid]
Stx1a	rgd:69430	[ENCODES a protein that exhibits ATP-dependent protein binding; calcium-dependent protein binding; ion channel binding; INVOLVED IN modulation of excitatory postsynaptic potential; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Creutzfeldt-Jakob disease (ortholog); FOUND IN actomyosin; glutamatergic synapse; integral component of presynaptic membrane; INTERACTS WITH (S)-amphetamine; ammonium chloride; amphetamine]
Ccn4	rgd:69431	[ENCODES a protein that exhibits insulin-like growth factor binding (inferred); INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; ASSOCIATED WITH Airway Remodeling; Experimental Liver Cirrhosis; Hyperoxia; FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether]
Ugt2a1	rgd:69432	[ENCODES a protein that exhibits glucuronosyltransferase activity (ortholog); INVOLVED IN sensory perception of smell; cellular glucuronidation (ortholog); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; FOUND IN integral component of membrane (inferred); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine]
Adrb2	rgd:2060	[ENCODES a protein that exhibits B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; aging; associative learning; PARTICIPATES IN G protein mediated signaling pathway via Galphai family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; epinephrine signaling pathway via adrenergic receptor beta; ASSOCIATED WITH acute kidney failure; congestive heart failure; dilated cardiomyopathy; FOUND IN axon; caveola; cytoplasm; INTERACTS WITH (5-hydroxyindol-3-yl)acetic acid; (R)-adrenaline; (R)-noradrenaline]
Adrb3	rgd:2061	[ENCODES a protein that exhibits epinephrine binding; norepinephrine binding; beta-3 adrenergic receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; aging; eating behavior; PARTICIPATES IN G protein mediated signaling pathway via Galphas family; calcium/calcium-mediated signaling pathway; endocytosis pathway; ASSOCIATED WITH colitis; congestive heart failure; Diabetes Mellitus, Experimental ; FOUND IN nucleus; membrane (ortholog); receptor complex (ortholog); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (R)-octopamine]
Grk2	rgd:2062	[ENCODES a protein that exhibits beta-adrenergic receptor kinase activity; delta-type opioid receptor binding; G protein-coupled receptor binding; INVOLVED IN aging; cellular response to catecholamine stimulus; cellular response to chemokine; PARTICIPATES IN dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway; somatostatin signaling pathway; ASSOCIATED WITH Burns; congestive heart failure; Diabetic Nephropathies; FOUND IN apical plasma membrane; axon; basolateral plasma membrane; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 2,6-dinitrotoluene]
Grk3	rgd:2063	[ENCODES a protein that exhibits beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; G protein-coupled receptor kinase activity; INVOLVED IN desensitization of G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; PARTICIPATES IN G protein mediated signaling pathway; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH Cardiomegaly; Diabetic Nephropathies; hypertension; FOUND IN axon; cilium; cytosol; INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; ammonium chloride]
Ap1b1	rgd:2064	[ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN clathrin coat assembly; determination of left/right symmetry (ortholog); heart development (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH Failure to Thrive (ortholog); Kartagener syndrome (ortholog); primary ciliary dyskinesia (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 4-tert-Octylphenol; acrylamide]
LOC102556377	rgd:7693265
LOC108353546	rgd:11490487
Afp	rgd:2065	[ENCODES a protein that exhibits metal ion binding (inferred); INVOLVED IN animal organ regeneration; liver development; pancreas development; PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH Alpha-Fetoprotein Deficiency (ortholog); Breast Neoplasms (ortholog); embryonal carcinoma (ortholog); FOUND IN cytoplasm; extracellular space; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (S)-naringenin]
Agrn	rgd:2067	[ENCODES a protein that exhibits BMP binding; calcium ion binding; dystroglycan binding; INVOLVED IN chemical synaptic transmission; positive regulation of filopodium assembly; positive regulation of GTPase activity; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; cell-extracellular matrix signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 8 (ortholog); FOUND IN axonal growth cone; basement membrane; glutamatergic synapse; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 3-chloropropane-1,2-diol]
Agrp	rgd:2068	[ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); INVOLVED IN adult feeding behavior; circadian rhythm; eating behavior; PARTICIPATES IN altered melanocortin system pathway; melanocortin system pathway; obesity pathway; ASSOCIATED WITH Hyperphagia; obesity; type 2 diabetes mellitus; FOUND IN extracellular space; neuronal cell body; Golgi lumen (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; ammonium chloride]