Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Adora2a	rgd:2049	[ENCODES a protein that exhibits alpha-actinin binding; G protein-coupled adenosine receptor activity; protein-containing complex binding; INVOLVED IN adenosine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; astrocyte activation; PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; lung disease; Reperfusion Injury; FOUND IN asymmetric synapse; axolemma; axon; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,4-dinitrotoluene]
LOC102552484	rgd:7536404
Cox4i2	rgd:69422	[ENCODES a protein that exhibits cytochrome-c oxidase activity (ortholog); INVOLVED IN cellular response to hypoxia; PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; ASSOCIATED WITH Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial Hyperostosis (ortholog); FOUND IN mitochondrial membrane (ortholog); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride]
Srebf1	rgd:69423	[ENCODES a protein that exhibits chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein-containing complex binding; INVOLVED IN aging; cellular response to fatty acid; cellular response to insulin stimulus; PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; insulin signaling pathway; ASSOCIATED WITH decreased cholesterol level; ASSOCIATED WITH alcoholic hepatitis; Diabetes Mellitus, Experimental ; Diabetic Nephropathies; FOUND IN intracellular membrane-bounded organelle; nucleus; protein-containing complex; INTERACTS WITH (+)-catechin; (-)-cotinine; (25R)-cholest-5-ene-3beta,26-diol]
Plce1	rgd:69424	[ENCODES a protein that exhibits phosphatidylinositol phospholipase C activity; Ras GTPase binding; enzyme binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway; Ras protein signal transduction; activation of MAPK activity (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); dengue hemorrhagic fever (ortholog); Diffuse Mesangial Sclerosis (ortholog); FOUND IN cytoplasm; cytosol (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl]
Ube2d4	rgd:69425	[ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to arsenite(3-); cellular response to cadmium ion; protein K11-linked ubiquitination (ortholog); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); INTERACTS WITH arsane; arsenic atom; bisphenol A]
Oprk1	rgd:69426	[ENCODES a protein that exhibits receptor serine/threonine kinase binding; dynorphin receptor activity (ortholog); opioid receptor activity (ortholog); INVOLVED IN behavioral response to cocaine; cellular response to glucose stimulus; cellular response to lipopolysaccharide; PARTICIPATES IN nalbuphine pharmacodynamics pathway; ASSOCIATED WITH Cardiac Arrhythmias; conditioned taste aversion; Diabetes Mellitus, Experimental ; FOUND IN axon terminus; dendrite; integral component of postsynaptic membrane; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol]
Pdk1	rgd:69427	[ENCODES a protein that exhibits ATP binding; identical protein binding; protein serine/threonine kinase activity; INVOLVED IN cell surface receptor signaling pathway; peptidyl-serine phosphorylation; protein phosphorylation; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; pyruvate metabolic pathway; FOUND IN pyruvate dehydrogenase complex; mitochondrial pyruvate dehydrogenase complex (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane]
Pdk2	rgd:69428	[ENCODES a protein that exhibits ATP binding; identical protein binding; protein serine/threonine kinase activity; INVOLVED IN peptidyl-serine phosphorylation; protein phosphorylation; cellular response to nutrient (ortholog); PARTICIPATES IN pyruvate metabolic pathway; ASSOCIATED WITH cardiomyopathy (ortholog); osteogenesis imperfecta type 1 (ortholog); FOUND IN mitochondrion; pyruvate dehydrogenase complex; cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene]
Sycp2	rgd:69429	[ENCODES a protein that exhibits protein heterodimerization activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); female meiotic nuclear division (ortholog); fertilization (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN lateral element; nucleus; synaptonemal complex; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 6-propyl-2-thiouracil]
Slc38a2	rgd:69420	[ENCODES a protein that exhibits L-glutamine transmembrane transporter activity; L-serine transmembrane transporter activity; amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport; cellular response to amino acid starvation; cellular response to mechanical stimulus; PARTICIPATES IN glutamate signaling pathway; ASSOCIATED WITH Contusions; Diabetes Mellitus, Experimental ; Fetal Growth Retardation; FOUND IN axon; brush border; dendrite; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene]
Ccdc80	rgd:69421	[ENCODES a protein that exhibits fibronectin binding (ortholog); glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); response to bacterium (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); interstitial matrix (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl]
Adora2b	rgd:2050	[ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); INVOLVED IN negative regulation of cell population proliferation; negative regulation of collagen biosynthetic process; positive regulation of blood vessel diameter; PARTICIPATES IN adenosine signaling pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH decreased inflammatory response; increased body weight; increased circulating interleukin-6 level; ASSOCIATED WITH Neoplasm Metastasis (ortholog); Reperfusion Injury (ortholog); Sepsis (ortholog); FOUND IN cell surface; plasma membrane; glutamatergic synapse (ortholog); INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine]
Adora3	rgd:2051	[ENCODES a protein that exhibits G protein-coupled adenosine receptor activity; INVOLVED IN G protein-coupled receptor signaling pathway; regulation of norepinephrine secretion; regulation of synaptic vesicle exocytosis; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); ischemia (ortholog); myocardial infarction (ortholog); FOUND IN presynaptic membrane; Schaffer collateral - CA1 synapse; integral component of plasma membrane (ortholog); INTERACTS WITH 2,4-dinitrobenzenesulfonic acid; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; acrylamide]
Adprh	rgd:2052	[ENCODES a protein that exhibits ADP-ribosylarginine hydrolase activity; magnesium ion binding (ortholog); potassium ion binding (ortholog); INVOLVED IN cellular protein modification process; protein de-ADP-ribosylation (ortholog); ASSOCIATED WITH Carcinogenesis (ortholog); FOUND IN cytosol; extracellular space; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bisphenol A]
Parp1	rgd:2053	[ENCODES a protein that exhibits enzyme binding; estrogen receptor binding; histone deacetylase binding; INVOLVED IN cellular response to amyloid-beta; cellular response to transforming growth factor beta stimulus; cellular response to zinc ion; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; base excision repair pathway; ASSOCIATED WITH borna disease; Carotid Artery Injuries; congestive heart failure; FOUND IN cytoplasm; nucleus; mitochondrion (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (+)-sesamin; (-)-anisomycin]
Adra1b	rgd:2054	[ENCODES a protein that exhibits alpha1-adrenergic receptor activity; protein heterodimerization activity (ortholog); INVOLVED IN negative regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration; response to drug; PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH polycystic ovary syndrome; Cardiomegaly (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN intercalated disc; membrane; T-tubule; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol]
Adra1a	rgd:2055	[ENCODES a protein that exhibits alpha1-adrenergic receptor activity; protein heterodimerization activity (ortholog); INVOLVED IN activation of phospholipase C activity; aging; calcium ion transport into cytosol; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH bladder neck obstruction; Brain Injuries; Diabetes Mellitus, Experimental ; FOUND IN dopaminergic synapse; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (R)-adrenaline; (R)-noradrenaline]
Adra2a	rgd:2056	[ENCODES a protein that exhibits alpha2-adrenergic receptor activity; adrenergic receptor activity (ortholog); alpha-1B adrenergic receptor binding (ortholog); INVOLVED IN acute inflammatory response; DNA replication; female pregnancy; ASSOCIATED WITH Acute Lung Injury; anxiety disorder; Endotoxemia; FOUND IN axon terminus; cytoplasm; GABA-ergic synapse; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran]
Adra2b	rgd:2057	[ENCODES a protein that exhibits alpha2-adrenergic receptor activity; adrenergic receptor activity (ortholog); epinephrine binding (ortholog); INVOLVED IN activation of MAPK activity; female pregnancy; positive regulation of blood pressure; ASSOCIATED WITH hypertension; Cyanosis (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cell surface (ortholog); INTERACTS WITH ammonium chloride; C60 fullerene; dibutyl phthalate]