Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Acy1	rgd:2030	[ENCODES a protein that exhibits aminoacylase activity; identical protein binding (ortholog); INVOLVED IN cellular amino acid metabolic process (inferred); protein catabolic process (inferred); proteolysis (inferred); PARTICIPATES IN arginine and proline metabolic pathway; ASSOCIATED WITH Aminoacylase 1 Deficiency (ortholog); pre-malignant neoplasm (ortholog); renal cell carcinoma (ortholog); FOUND IN extracellular exosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine]
LOC103690678	rgd:9177365
Ada	rgd:2031	[ENCODES a protein that exhibits adenosine deaminase activity; purine nucleoside binding; zinc ion binding (ortholog); INVOLVED IN adenosine metabolic process; aging; histamine secretion; PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental ; hyperglycemia; FOUND IN cytoplasm; dendrite cytoplasm; extracellular space; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol]
Adam10	rgd:2032	[ENCODES a protein that exhibits metalloendopeptidase activity; endopeptidase activity (ortholog); metalloendopeptidase activity involved in amyloid precursor protein catabolic process (ortholog); INVOLVED IN amyloid-beta formation; positive regulation of apoptotic process; regulation of dendritic spine morphogenesis; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Alzheimer's disease; Brain Injuries, Traumatic; cardiomyopathy; FOUND IN cell surface; dendrite; dendritic spine; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrolein]
Adarb1	rgd:2033	[ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; identical protein binding; INVOLVED IN adenosine to inosine editing; base conversion or substitution editing; brain development; PARTICIPATES IN microRNA pathway; ASSOCIATED WITH obesity; Spinal Cord Injuries; transient cerebral ischemia; FOUND IN nucleolus; nucleoplasm; cytosol (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline]
Adcy4	rgd:2034	[ENCODES a protein that exhibits adenylate cyclase activity; G-protein beta/gamma-subunit complex binding; protein kinase C binding (ortholog); INVOLVED IN cAMP biosynthetic process; intracellular signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane; nucleus; protein-containing complex; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl]
Adcy6	rgd:2035	[ENCODES a protein that exhibits adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity; protein kinase binding; INVOLVED IN cAMP biosynthetic process; circadian rhythm; maintenance of protein location in plasma membrane; PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH ureteral obstruction; Lethal Congenital Contracture Syndrome 8 (ortholog); FOUND IN endosome; membrane; membrane raft; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene]
Adcy8	rgd:2036	[ENCODES a protein that exhibits actin binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; INVOLVED IN activation of protein kinase A activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton; caveola; clathrin-coated pit; INTERACTS WITH 6-propyl-2-thiouracil; beta-naphthoflavone; bisphenol A]
Adcyap1	rgd:2037	[ENCODES a protein that exhibits neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; pituitary adenylate cyclase-activating polypeptide receptor binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; ATP metabolic process; behavioral fear response; ASSOCIATED WITH Acute Necrotizing Pancreatitis; Brain Injuries; cystitis; FOUND IN extracellular space; terminal bouton; INTERACTS WITH 17alpha-ethynylestradiol; alendronic acid; ammonium chloride]
Adcyap1r1	rgd:2038	[ENCODES a protein that exhibits adenylate cyclase binding; ADP-ribosylation factor binding; neuropeptide binding; INVOLVED IN activation of phospholipase C activity; cAMP-mediated signaling; development of primary female sexual characteristics; ASSOCIATED WITH cystitis; Reperfusion Injury; asthma (ortholog); FOUND IN bicellular tight junction; caveola; cell surface; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cyclophosphamide]
LOC102547705	rgd:7742786
LOC102550675	rgd:7703180
Add1	rgd:2041	[ENCODES a protein that exhibits T cell receptor binding; actin filament binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to retinoic acid; negative regulation of actin filament polymerization; positive regulation of angiogenesis; ASSOCIATED WITH increased systemic arterial systolic blood pressure; ASSOCIATED WITH hypertension; temporal lobe epilepsy; atherosclerosis (ortholog); FOUND IN dendrite; dendritic spine; perinuclear region of cytoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole]
LOC102556774	rgd:7693286
Add2	rgd:2042	[ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN ion transport; actin filament bundle assembly (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH hypertension; hereditary spherocytosis type 1 (ortholog); IgA glomerulonephritis (ortholog); FOUND IN glutamatergic synapse; postsynapse; cytoplasmic vesicle (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acrylamide]
Add3	rgd:2043	[ENCODES a protein that exhibits protein kinase C binding; structural constituent of cytoskeleton (ortholog); INVOLVED IN positive regulation of vasoconstriction; response to drug; ASSOCIATED WITH hypertension; Urinary Calculi; bipolar disorder (ortholog); FOUND IN cytoskeleton; brush border (ortholog); cell cortex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,4-dinitrotoluene]
Adh1	rgd:2044	[ENCODES a protein that exhibits alcohol dehydrogenase (NAD+) activity; drug binding; ethanol binding; INVOLVED IN acetaldehyde biosynthetic process; animal organ regeneration; ethanol oxidation; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol; intracellular (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate]
Adk	rgd:2046	[ENCODES a protein that exhibits adenosine kinase activity; INVOLVED IN adenosine metabolic process; circadian regulation of gene expression; positive regulation of cardiac muscle hypertrophy; PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH brain infarction; Diabetes Mellitus, Experimental ; Experimental Arthritis; FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4'-hydroxyacetophenone]
Adm	rgd:2047	[ENCODES a protein that exhibits adrenomedullin receptor binding; INVOLVED IN aging; androgen metabolic process; animal organ regeneration; PARTICIPATES IN p38 MAPK signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Acidoses; Cardiac Arrhythmias; congestive heart failure; FOUND IN extracellular space; cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one]
Adora1	rgd:2048	[ENCODES a protein that exhibits G protein-coupled adenosine receptor activity; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; INVOLVED IN activation of MAPKK activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cognition; ASSOCIATED WITH cerebral infarction; Diabetes Mellitus, Experimental ; Diabetic Nephropathies; FOUND IN asymmetric synapse; axolemma; basolateral plasma membrane; INTERACTS WITH (+)-pilocarpine; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,4-dithiothreitol]