Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
NADPH--cytochrome P450 reductase	P00388	[Function: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.]
Putative gamma-secretase subunit APH-1C	Q9DCZ9	[Function: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein).]
Cytochrome b-c1 complex subunit 9	Q8R1I1	[Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).]
NADH-cytochrome b5 reductase 3	P00387	[Function: Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.]
Zinc finger CCHC domain-containing protein 9	Q8R1J3	[Function: May down-regulate transcription mediated by NF-kappa-B and the serum response element.]
Torsin-2A	Q8R1J9
Leucine-rich repeat-containing protein 72	A6NJI9
Vesicle transport protein SFT2C	Q587I9	[Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.]
cAMP-dependent protein kinase type II-alpha regulatory subunit	P12367	[Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.]
cAMP-dependent protein kinase type II-alpha regulatory subunit	P12368	[Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.]
Cytochrome c	P99999	[Function: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.]
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	[Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.]
Doublesex and mab-3 related transcription factor 3	D4A218	[Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).]
PH domain leucine-rich repeat-containing protein phosphatase 2	Q6ZVD8	[Function: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).]
Thyrotropin-releasing hormone-degrading ectoenzyme	Q10836	[Function: Specific inactivation of TRH after its release.]
Storkhead-box protein 1	Q6ZVD7	[Function: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).]
Microtubule-associated serine/threonine-protein kinase 4	Q811L6
High affinity immunoglobulin epsilon receptor subunit alpha	P12371	[Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.]
Transducin-like enhancer protein 7	A0A1W2PR48
Rho-related GTP-binding protein RhoD	P97348	[Function: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.]