Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Occludin	Q6P6T5	[Function: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells.]
Echinoderm microtubule-associated protein-like 2	Q6P6T4	[Function: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.]
Coiled-coil domain-containing protein 121	Q6ZUS5
Monocyte to macrophage differentiation factor 2	Q8R189
Adaptin ear-binding coat-associated protein 2	Q6P756	[Function: Involved in endocytosis.]
Desumoylating isopeptidase 1	Q6ICB0	[Function: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234).]
Complement C1s subcomponent	Q6P6T1	[Function: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity).]
Epididymal-specific lipocalin-10	Q810Z1	[Function: May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.]
Coiled-coil domain-containing protein 149	Q6ZUS6
Torsin-1A-interacting protein 2	Q6P752	[Function: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity).]
Heterochromatin protein 1-binding protein 3	Q6P747	[Function: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.]
Ectonucleoside triphosphate diphosphohydrolase 5	Q6P6S9	[Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity).]
Tetraspanin-4	Q9DCK3
Uncharacterized protein C9orf57	Q5W0N0
Zinc finger protein 414	Q9DCK4	[Function: May be involved in transcriptional regulation.]
Wilms tumor protein 1-interacting protein	A6NIX2	[Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).]
CDK2-associated and cullin domain-containing protein 1	Q8R0X2	[Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.]
Keratin, type II cytoskeletal 72	Q14CN4	[Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).]
Calcium-activated chloride channel regulator 4	Q14CN2	[Function: May be involved in mediating calcium-activated chloride conductance.]
Sphingosine-1-phosphate lyase 1	Q8R0X7	[Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).]