Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
S-acyl fatty acid synthase thioesterase, medium chain	Q8R197	[Function: Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).]
Nucleotide exchange factor SIL1	Q6P6S4	[Function: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity).]
ATP-binding cassette sub-family D member 1	P48410	[Function: Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:25255441, PubMed:9418970, PubMed:9126326, PubMed:9256488, PubMed:18854420, PubMed:23123468, PubMed:26108493, PubMed:23604518, PubMed:25583114). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:26108493, PubMed:15489218). Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization (PubMed:25583114, PubMed:23604518, PubMed:18344354, PubMed:22521832). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473).]
B box and SPRY domain-containing protein	Q6P6S3	[Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity.]
Tail-anchored protein insertion receptor WRB	Q6P6S5	[Function: Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.]
Synaptosomal-associated protein 47	Q6P6S0	[Function: May play a role in intracellular membrane fusion.]
Doublecortin domain-containing protein 1	M0R2J8	[Function: Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).]
Zinc transporter ZIP11	Q6P6S2	[Function: Functions as a cellular zinc transporter.]
Proteolipid protein 2	Q6P742	[Function: May play a role in cell differentiation in the intestinal epithelium.]
Purine nucleoside phosphorylase	P00491	[Function: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.]
Hypoxanthine-guanine phosphoribosyltransferase	P00493	[Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).]
Equatorin	Q2LCV6	[Function: Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.]
Hypoxanthine-guanine phosphoribosyltransferase	P00492	[Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.]
TM2 domain-containing protein 2	Q8R0I4
Cytochrome P450 3A7	P24462	[Function: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:9555064, PubMed:17178770). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:14559847, PubMed:12865317). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064).]
Cytochrome P450 20A1	Q6P7D4
Immediate early response gene 2 protein	Q6P7D3	[Function: DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (PubMed:17156131). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).]
Mid1-interacting protein 1	Q6P7D5	[Function: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).]
Sphingosine-1-phosphate phosphatase 2	Q810K3	[Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (PubMed:27059959).]
Homeobox protein Nkx-6.3	A6NJ46	[Function: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.]