Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| SLIT-ROBO Rho GTPase-activating protein 2B | P0DMP2 | [Function: May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.] |
| Humanin-like 12 | P0DMP1 | [Function: Plays a role as a neuroprotective and antiapoptotic factor.] |
| Progonadoliberin-1 | P13562 | [Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.] |
| Transcription factor E4F1 | Q66K89 | [Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.] |
| Seven in absentia homolog 3 | Q8IW03 | [Function: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.] |
| Putative uncharacterized protein RUSC1-AS1 | Q66K80 | |
| Interferon gamma | P01579 | [Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.] |
| V-set and transmembrane domain-containing protein 4 | Q8IW00 | [Function: Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.] |
| Thymocyte selection-associated high mobility group box protein TOX | Q66JW3 | [Function: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (PubMed:25527292, PubMed:20818394, PubMed:11850626, PubMed:18195075, PubMed:15078895, PubMed:25915732). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA (PubMed:25527292, PubMed:31207603, PubMed:31207604). During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (PubMed:25527292). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches (PubMed:20818394). Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment (PubMed:11850626, PubMed:18195075). Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells (PubMed:18195075, PubMed:15078895). Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage (PubMed:25915732). Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:20818394). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (PubMed:31207603, PubMed:31207604).] |
| Interferon beta | P01574 | [Function: Has antiviral, antibacterial and anticancer activities.] |
| Interferon beta | P01575 | [Function: Has antiviral, antibacterial and anticancer activities.] |
| Interferon alpha-1 | P01572 | [Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.] |
| Interferon alpha-2 | P01573 | [Function: Produced by macrophages, IFN-alpha have antiviral activities.] |
| Immunoglobulin J chain | P01592 | [Function: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.] |
| Immunoglobulin kappa variable 1D-33 | P01593 | [Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).] |
| 3-hydroxyanthranilate 3,4-dioxygenase | Q78JT3 | [Function: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.] |
| Interleukin-2 receptor subunit alpha | P01590 | [Function: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.] |
| Synaptonemal complex protein 2-like | A0A0M3U1B0 | [Function: Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes.] |
| Immunoglobulin J chain | P01591 | [Function: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.] |
| Cell surface glycoprotein CD200 receptor 2 | Q6Q8B3 | [Function: May be a receptor for the CD200/OX2 cell surface glycoprotein.] |