Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Uncharacterized protein C8orf58 homolog	Q66JV7
Zinc finger protein 547	Q8IVP9	[Function: May be involved in transcriptional regulation.]
Aprataxin and PNK-like factor	Q8IW19	[Function: Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721).]
Microtubule-associated protein 1S	Q66K74	[Function: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).]
RNA-binding protein 12B-B	Q66JV4
FUN14 domain-containing protein 1	Q8IVP5	[Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.]
Carboxypeptidase Z	Q66K79	[Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.]
Interleukin-2 receptor subunit alpha	P01589	[Function: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.]
Granulocyte-macrophage colony-stimulating factor	P01587	[Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.]
Erythropoietin	P01588	[Function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.]
Interleukin-3	P01586	[Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.]
Interleukin-1 alpha	P01583	[Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.]
Interleukin-1 beta	P01584	[Function: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).]
Sulfotransferase 1A4	P0DMN0	[Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.]
Myosin-3	P13541	[Function: Muscle contraction.]
Myosin-8	P13542	[Function: Muscle contraction.]
Proline-rich protein 20B	P86481
Transmembrane protein 198	Q66K66	[Function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.]
DDB1- and CUL4-associated factor 15	Q66K64	[Function: May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.]
S-adenosylmethionine decarboxylase proenzyme 1	P0DMN7	[Function: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.]