Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Condensin complex subunit 3 | Q9BPX3 | [Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.] |
| Spectrin beta chain, non-erythrocytic 1 | Q62261 | [Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.] |
| 17-beta-hydroxysteroid dehydrogenase 14 | Q9BPX1 | [Function: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).] |
| UPF0415 protein C7orf25 | Q9BPX7 | |
| Thyroid hormone-inducible hepatic protein | Q62264 | [Function: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).] |
| Actin-related protein 2/3 complex subunit 5-like protein | Q9BPX5 | [Function: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.] |
| Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Q9BQ95 | [Function: Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.] |
| Cornifin-A | Q62266 | [Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility.] |
| Calcium uptake protein 1, mitochondrial | Q9BPX6 | [Function: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).] |
| Cornifin-B | Q62267 | [Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.] |
| Zinc finger protein 776 | Q68DI1 | [Function: May be involved in transcriptional regulation.] |
| Tubulin epsilon and delta complex protein 1 | Q3UK37 | [Function: Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (PubMed:29459677). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (By similarity).] |
| Kelch domain-containing protein 3 | Q9BQ90 | [Function: May be involved in meiotic recombination process.] |
| Tyrosine-protein kinase Srms | Q62270 | [Function: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent.] |
| Rho guanine nucleotide exchange factor 19 | Q8BWA8 | [Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.] |
| Histone chaperone ASF1A | Q9Y294 | [Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.] |
| Developmentally-regulated GTP-binding protein 1 | Q9Y295 | [Function: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).] |
| Trafficking protein particle complex subunit 4 | Q9Y296 | [Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.] |
| Kelch-like protein 31 | Q8BWA5 | [Function: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity).] |
| 28S ribosomal protein S33, mitochondrial | Q9Y291 |