Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Rho GTPase-activating protein 27 | A2AB59 | [Function: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).] |
| V-set and immunoglobulin domain-containing protein 4 | Q9Y279 | [Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.] |
| Synaptopodin 2-like protein | Q8BWB1 | [Function: Actin-associated protein that may play a role in modulating actin-based shape.] |
| Tumor necrosis factor ligand superfamily member 13B | Q9Y275 | [Function: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.] |
| Mitochondrial chaperone BCS1 | Q9Y276 | [Function: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.] |
| Voltage-dependent anion-selective channel protein 3 | Q9Y277 | [Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.] |
| Heparan sulfate glucosamine 3-O-sulfotransferase 2 | Q9Y278 | [Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.] |
| ALX homeobox protein 1 | Q8C8B0 | [Function: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:8673125). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity).] |
| Synaptotagmin-13 | Q7L8C5 | [Function: May be involved in transport vesicle docking to the plasma membrane.] |
| Protein FAM118B | Q9BPY3 | [Function: May play a role in Cajal bodies formation.] |
| Sperm surface protein Sp17 | Q62252 | [Function: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).] |
| Homeodomain-only protein | Q9BPY8 | [Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).] |
| Sal-like protein 3 | Q62255 | [Function: Probable transcription factor.] |
| Cation channel sperm-associated protein subunit beta | A2RTF1 | [Function: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.] |
| GRB2-associated and regulator of MAPK protein 2 | Q75VX8 | [Function: Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.] |
| Tumor protein p53-inducible protein 13 | Q5F267 | [Function: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity).] |
| Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B | Q8N8A2 | [Function: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.] |
| G-protein coupled receptor-associated protein LMBRD2 | Q68DH5 | [Function: Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable).] |
| ATP-dependent RNA helicase DDX51 | Q8N8A6 | [Function: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.] |
| Protein FAM169B | Q8N8A8 |