Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
La-related protein 4	Q8BWW4	[Function: RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization.]
Neurexin-3-beta	Q8C985	[Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).]
Cytosolic endo-beta-N-acetylglucosaminidase	Q8BX80	[Function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (By similarity).]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3	O95803	[Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.]
Transmembrane protein 50A	O95807
Zinc finger protein 709	Q8N972	[Function: May be involved in transcriptional regulation.]
Guanylate-binding protein 7	Q8N8V2	[Function: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).]
Sterol regulatory element-binding protein cleavage-activating protein	A2RRU4	[Function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).]
U3 small nucleolar RNA-associated protein 15 homolog	A2RRU3	[Function: Involved in nucleolar processing of pre-18S ribosomal RNA.]
Spermatogenesis-associated protein 25	Q9BR10	[Function: May play a role in spermatogenesis.]
Zinc finger protein 557	Q8N988	[Function: May be involved in transcriptional regulation.]
N-acetylglucosamine-6-phosphate deacetylase	Q9Y303	[Function: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.]
Zinc finger SWIM domain-containing protein 1	Q9BR11
N-terminal EF-hand calcium-binding protein 1	Q8N987
Swi5-dependent recombination DNA repair protein 1 homolog	Q6TXG9	[Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1.]
Chloride intracellular channel protein 3	O95833	[Function: Can insert into membranes and form chloride ion channels. May participate in cellular growth control.]
Echinoderm microtubule-associated protein-like 2	O95834	[Function: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.]
Mitochondrial genome maintenance exonuclease 1	Q9BQP7	[Function: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.]
Apoptosis-inducing factor 1, mitochondrial	O95831	[Function: Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.]
Claudin-1	O95832	[Function: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010). Acts as a receptor for dengue virus (PubMed:24074594).]