Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Acyl-coenzyme A thioesterase 9, mitochondrial | Q9Y305 | [Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.] |
| Oxysterol-binding protein-related protein 2 | Q8BX94 | [Function: Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).] |
| Transmembrane protein 163 | Q8C996 | [Function: May bind zinc and other divalent cations and recruit them to vesicular organelles.] |
| Guanine nucleotide-binding protein subunit alpha-14 | O95837 | [Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.] |
| Neuralized-like protein 2 | Q9BR09 | [Function: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).] |
| Fibronectin type-III domain-containing protein 3A | Q8BX90 | [Function: Mediates spermatid-Sertoli adhesion during spermatogenesis.] |
| Glucagon-like peptide 2 receptor | O95838 | [Function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.] |
| Pejvakin | Q0ZLH2 | [Function: Essential in the activity of auditory pathway neurons.] |
| Serine/threonine-protein kinase LATS1 | O95835 | [Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).] |
| Pejvakin | Q0ZLH3 | [Function: Essential in the activity of auditory pathway neurons.] |
| Protein transport protein Sec23A | Q01405 | [Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (By similarity). Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (PubMed:27354378).] |
| Patatin-like phospholipase domain-containing protein 1 | Q8N8W4 | [Function: Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.] |
| 39S ribosomal protein L43, mitochondrial | Q8N983 | |
| Glycogen [starch] synthase, muscle | A2RRU1 | [Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.] |
| Golgi reassembly-stacking protein 1 | Q9BQQ3 | [Function: Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069). Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).] |
| Leucine-rich repeat-containing protein 66 | Q6TXF5 | |
| Uncharacterized protein C12orf29 | Q8N999 | |
| Protein mab-21-like 3 | Q8N8X9 | |
| Coiled-coil domain-containing protein 89 | Q8N998 | |
| Receptor-transporting protein 3 | Q9BQQ7 | [Function: Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.] |