Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Malonyl-CoA decarboxylase, mitochondrial	O95822	[Function: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.]
Cytochrome P450 4V2	A2RRT9	[Function: Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA).]
Osteoclast stimulatory transmembrane protein	Q9BR26	[Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).]
Tyrosine-protein kinase STYK1	Q6J9G1	[Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.]
Tyrosine-protein kinase STYK1	Q6J9G0	[Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).]
Arrestin domain-containing protein 3	Q6TXF1	[Function: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.]
Hypoxia-inducible factor 3-alpha	Q9Y2N7	[Function: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.]
Protein CIP2A	Q8BWY9	[Function: Promotes anchorage-independent cell growth and tumor formation.]
N-acetylgalactosamine kinase	Q01415	[Function: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.]
Metallo-beta-lactamase domain-containing protein 1	Q8BWY4
Sterile alpha motif domain-containing protein 7	Q8C8Y5	[Function: Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.]
Zinc transporter ZIP11	Q8BWY7	[Function: Functions as a cellular zinc transporter.]
Transcription factor Dp family member 3	Q5H9I0	[Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.]
C-type lectin domain family 1 member A	Q8BWY2
BPI fold-containing family A member 3	Q9BQP9
Eukaryotic peptide chain release factor subunit 1	Q8BWY3	[Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).]
Quinone oxidoreductase-like protein 1	O95825
RNA-binding motif, single-stranded-interacting protein 1	P29558	[Function: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.]
Glutathione S-transferase kappa 1	Q9Y2Q3	[Function: Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).]
rRNA-processing protein FCF1 homolog	Q9Y324	[Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.]