Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Ragulator complex protein LAMTOR2	Q9Y2Q5	[Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.]
Serine protease 27	Q9BQR3
Junctophilin-2	Q9BR39	[Function: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.]
Phospholipid-transporting ATPase IA	Q9Y2Q0	[Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.]
Thioredoxin-related transmembrane protein 2	Q9Y320
Zinc finger protein 257	Q9Y2Q1	[Function: May be involved in transcriptional regulation.]
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3	H0UI37
Docking protein 6	Q6PKX4	[Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.]
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	P17568	[Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.]
Neuronal vesicle trafficking-associated protein 2	Q9Y328
28S ribosomal protein S28, mitochondrial	Q9Y2Q9
V-type proton ATPase subunit d 2	Q8N8Y2	[Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).]
N-alpha-acetyltransferase 25, NatB auxiliary subunit	Q8BWZ3	[Function: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.]
Zinc finger protein 41 homolog	Q8N8Y5	[Function: A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.]
Protein AAR2 homolog	Q9Y312	[Function: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.]
Zinc finger protein 441	Q8N8Z8	[Function: May be involved in transcriptional regulation.]
Putative uncharacterized protein C20orf78	Q9BR46
Heat shock protein beta-9	Q9BQS6
Dynamin-binding protein	Q6TXD4	[Function: Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (PubMed:14506234).]
Nitric oxide synthase-interacting protein	Q9Y314	[Function: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).]