Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Glucagon-like peptide 2 receptor	Q5IXF8	[Function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).]
N(6)-adenine-specific DNA methyltransferase METTL4	Q8N3J2	[Function: N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) and is required to regulate Polycomb silencing. N(6)-methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing.]
Kelch repeat and BTB domain-containing protein 8	B1H285	[Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.]
Lymphocyte expansion molecule	B1H283
Uncharacterized protein C17orf53	Q8N3J3
Cell adhesion molecule 2	Q8N3J6	[Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.]
Protein phosphatase 1K, mitochondrial	Q8N3J5	[Function: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.]
Centromere protein U	Q71F23	[Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.]
Zinc finger protein 708	P17019	[Function: May be involved in transcriptional regulation.]
G2/mitotic-specific cyclin-B2	O95067	[Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.]
Guanylate cyclase soluble subunit alpha-1	P19686
RELT-like protein 2	Q8BRJ3	[Function: Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed.]
Zinc finger protein 664	Q8N3J9	[Function: May be involved in transcriptional regulation.]
Zinc finger protein 14	P17017	[Function: May be involved in transcriptional regulation.]
Protein phosphatase 1 regulatory subunit 3E	Q8BRJ4	[Function: Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.]
Dedicator of cytokinesis protein 2	Q8C3J5	[Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.]
Zinc finger protein 22	P17026	[Function: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).]
Zinc finger protein 182	P17025	[Function: May be involved in transcriptional regulation.]
Zinc finger protein 20	P17024	[Function: May be involved in transcriptional regulation.]
Monoacylglycerol lipase ABHD2	Q9QXM0	[Function: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306).]