Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Zinc finger protein 19	P17023	[Function: May be involved in transcriptional regulation.]
Zinc finger protein 18	P17022	[Function: May be involved in transcriptional regulation.]
Zinc finger protein 17	P17021	[Function: May be involved in transcriptional regulation.]
Junction-mediating and -regulatory protein	Q9QXM1	[Function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.]
Protein YIF1A	O95070	[Function: Possible role in transport between endoplasmic reticulum and Golgi.]
MORN repeat-containing protein 3	Q6PF18
Zinc finger protein 16	P17020	[Function: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.]
Kelch-like protein 35	Q6PF15
DNA primase small subunit	P20664	[Function: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8253737, PubMed:8026492). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Can add both ribo- and deoxynucleotides during elongation of the primers (PubMed:8253737). Binds single stranded DNA (PubMed:8253737).]
Zinc finger Y-chromosomal protein 2	P20662	[Function: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).]
Olfactory receptor 4F21	O95013	[Function: Odorant receptor.]
Protein FAM72D	Q6L9T8
Helicase SKI2W	Q15477	[Function: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).]
Dolichol-phosphate mannosyltransferase subunit 3	Q9P2X0	[Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.]
VIP peptides	P32648	[Function: PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHM also causes vasodilation.]
Protein IMPACT	Q9P2X3	[Function: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.]
Nuclear pore membrane glycoprotein 210	Q8TEM1	[Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.]
Deleted in esophageal cancer 1	Q9P2X7	[Function: Candidate tumor suppressor.]
Putative uncharacterized protein encoded by LINC00474	Q9P2X8
Short transient receptor potential channel 4-associated protein	Q8TEL6	[Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.]