Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Serine/threonine-protein kinase ULK3 | Q6PHR2 | [Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.] |
| Myosin light chain 4 | P17209 | [Function: Regulatory light chain of myosin. Does not bind calcium.] |
| POU domain, class 4, transcription factor 1 | P17208 | [Function: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1 (PubMed:12934100). Does not have antiapoptotic effect on neuronal cells (PubMed:9722627).] |
| Ammonium transporter Rh type C | Q7TNN9 | [Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).] |
| Acyl-CoA wax alcohol acyltransferase 1 | Q58HT5 | [Function: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038).] |
| C-X-C motif chemokine 2 | P19875 | [Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.] |
| Coatomer subunit gamma-2 | D4ABY2 | [Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).] |
| Bactericidal permeability-increasing protein | P17213 | [Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.] |
| Digestive organ expansion factor homolog | Q8BTT6 | [Function: Regulates the p53 pathway to control the expansion growth of digestive organs.] |
| Serine racemase | Q9QZX7 | [Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.] |
| Cytochrome P450 2A5 | P20852 | [Function: Exhibits a high coumarin 7-hydroxylase activity.] |
| Coiled-coil domain-containing protein 113 | Q8C5T8 | [Function: Component of centriolar satellites contributing to primary cilium formation.] |
| Centrosomal protein of 19 kDa | Q9QZX9 | [Function: Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.] |
| Cytochrome P450 2A7 | P20853 | [Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.] |
| N-alpha-acetyltransferase 35, NatC auxiliary subunit | Q6PHQ8 | [Function: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.] |
| Solute carrier organic anion transporter family member 1B2 | Q9QZX8 | [Function: Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.] |
| Protein cornichon homolog 2 | Q6PI25 | [Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.] |
| Protein SHQ1 homolog | Q6PI26 | [Function: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.] |
| MORN repeat-containing protein 3 | Q8C5T4 | |
| Putative uncharacterized protein TRPC5OS homolog | Q3UHV4 |