Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Septin-10 | Q8C650 | [Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).] |
| Fibroblast growth factor 1 | P05230 | [Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).] |
| BPI fold-containing family B member 6 | Q8BU51 | |
| Interleukin-6 | P05231 | [Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.] |
| Collagen alpha-1(IX) chain | P20850 | [Function: Structural component of hyaline cartilage and vitreous of the eye.] |
| Solute carrier family 25 member 41 | Q8N5S1 | |
| C4b-binding protein beta chain | P20851 | [Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.] |
| Peroxisomal bifunctional enzyme | P07896 | |
| Uncharacterized protein C2orf73 | Q8N5S3 | |
| Superoxide dismutase [Mn], mitochondrial | P07895 | [Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.] |
| Tubulin alpha-1B chain | P05213 | [Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.] |
| Tubulin alpha-3 chain | P05214 | [Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.] |
| ATP-dependent RNA helicase DDX3Y | Q62095 | [Function: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.] |
| Collagen alpha-1(IX) chain | P20849 | [Function: Structural component of hyaline cartilage and vitreous of the eye.] |
| Phospholipid-transporting ATPase 11C | Q9QZW0 | [Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate phosphatidylserine (PS) flipping in pro-B cells (PubMed:21423172). May be involved in the transport of cholestatic bile acids (PubMed:21518881).] |
| Golgin subfamily A member 8Q | H3BV12 | |
| Olfactomedin-like protein 2A | Q68BL7 | |
| RCC1 domain-containing protein 1 | Q8BTU7 | [Function: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.] |
| E3 ubiquitin-protein ligase pellino homolog 1 | Q8C669 | [Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (By similarity).] |
| Ubiquilin-3 | Q8C5U9 |