Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
BAG family molecular chaperone regulator 4	O95429	[Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.]
Mas-related G-protein coupled receptor member B8	Q7TN51	[Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).]
Aspartyl/asparaginyl beta-hydroxylase	Q8BSY0	[Function: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.]
Negative elongation factor B	Q8C4Y3	[Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II) (PubMed:25773599). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (PubMed:19340312). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (PubMed:25773599). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (PubMed:24656816).]
Protein FAM222A	Q6PGH4
Pre T-cell antigen receptor alpha	Q6ISU1	[Function: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.]
Plasma membrane calcium-transporting ATPase 3	Q64568	[Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.]
Transmembrane channel-like protein 8	Q7TN58	[Function: Probable ion channel.]
Brain-specific angiogenesis inhibitor 1-associated protein 2	Q6GMN2	[Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).]
MIEF1 upstream open reading frame protein	L0R8F8	[Function: Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).]
Tripeptidyl-peptidase 2	Q64560	[Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).]
Steroid 21-hydroxylase	Q64562	[Function: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.]
All-trans-retinol dehydrogenase [NAD(+)] ADH4	Q64563	[Function: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (By similarity). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Also catalyzes the reduction of benzoquinones (By similarity).]
Calcium-transporting ATPase type 2C member 1	Q64566	[Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.]
Low-density lipoprotein receptor-related protein 5-like protein	A4QPB2
Alanine--glyoxylate aminotransferase 2, mitochondrial	Q64565	[Function: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).]
EF-hand calcium-binding domain-containing protein 4A	Q8N4Y2	[Function: Plays a role in store-operated Ca(2+) entry (SOCE).]
Guanine nucleotide-binding protein-like 3-like protein	Q6PGG6	[Function: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity).]
Transmembrane channel-like protein 6	Q7TN60	[Function: Probable ion channel.]
AP-3 complex subunit sigma-2	Q8BSZ2	[Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.]