Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| GEM-interacting protein | Q6PGG2 | [Function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA.] |
| Cytosolic acyl coenzyme A thioester hydrolase | Q64559 | [Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:7906114). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:7906114). May play an important physiological function in brain (PubMed:7906114).] |
| Leukocyte-associated immunoglobulin-like receptor 2 | Q6ISS4 | |
| Opioid-binding protein/cell adhesion molecule | P32736 | [Function: Binds opioids in the presence of acidic lipids; probably involved in cell contact.] |
| Choline O-acetyltransferase | P32738 | [Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.] |
| UDP-glucuronosyltransferase 1-1 | Q64550 | [Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin.] |
| Butyrophilin subfamily 2 member A2 | A4QPC6 | [Function: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.] |
| Serine/threonine-protein kinase Nek10 | Q3UGM2 | |
| Ras-related protein Rab-42 | Q8N4Z0 | |
| Exocyst complex component 8 | Q6PGF7 | [Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.] |
| Retrotransposon-derived protein PEG10 | Q7TN75 | [Function: May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.] |
| N-acetylneuraminate 9-O-acetyltransferase | Q7TN73 | [Function: O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition.] |
| FAST kinase domain-containing protein 5, mitochondrial | Q7TMV3 | [Function: Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.] |
| Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase | D4AD37 | [Function: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.] |
| Mediator of RNA polymerase II transcription subunit 16 | Q6PGF3 | [Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).] |
| E3 ubiquitin-protein ligase RNF139 | Q7TMV1 | [Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.] |
| MORN repeat-containing protein 4 | Q6PGF2 | [Function: Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.] |
| Carbonic anhydrase 5B, mitochondrial | Q9QZA0 | [Function: Reversible hydration of carbon dioxide.] |
| Programmed cell death 6-interacting protein | Q9QZA2 | [Function: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).] |
| Reticulon-1 | Q64548 | [Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.] |