Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Olfactory receptor 507	Q8VG13	[Function: Potential odorant receptor.]
Paired box protein Pax-4	P32115	[Function: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.]
Keratin, type II cuticular Hb4	Q99M73
Paired box protein Pax-2	P32114	[Function: Transcription factor that may have a role in kidney cell differentiation.]
T cell receptor beta variable 5-5	A0A597	[Function: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).]
Sodium-dependent multivitamin transporter	Q5U4D8	[Function: Transports pantothenate, biotin and lipoate in the presence of sodium.]
PAN2-PAN3 deadenylation complex subunit PAN3	Q58A45	[Function: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.]
Prostate collagen triple helix protein	Q58A44	[Function: May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.]
THO complex subunit 6 homolog	Q5U4D9	[Function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity).]
Olfactory receptor 497	Q8VG08	[Function: Potential odorant receptor.]
Olfactory receptor 494	Q8VG07	[Function: Potential odorant receptor.]
Olfactory receptor 502	Q8VG09	[Function: Potential odorant receptor.]
Arylsulfatase J	Q8BM89
MAM and LDL-receptor class A domain-containing protein 1	Q5VYJ5	[Function: Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.]
Gastricsin	P20142	[Function: Hydrolyzes a variety of proteins.]
mRNA decay activator protein ZFP36L3	Q5ISE2	[Function: Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:15814898, PubMed:26952984). Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG (PubMed:15814898, PubMed:18367448, PubMed:26952984). Involved in placental expression of many genes important for normal placental physiology (PubMed:26952984).]
TBC domain-containing protein kinase-like protein	Q8BM85	[Function: Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.]
LHFPL tetraspan subfamily member 6 protein	Q8BM86
Cathepsin O	Q8BM88	[Function: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.]
Nesprin-4	Q8N205	[Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).]