Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Nuclear receptor subfamily 6 group A member 1	Q64249	[Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.]
Transmembrane protease serine 11E	Q5S248	[Function: Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.]
Vitamin D 25-hydroxylase	Q6VVX0	[Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).]
Protein AMBP	Q64240	[Function: Trypstatin is a trypsin inhibitor. It inhibits blood coagulation factor Xa and tryptase about 100-fold more rapidly than porcine pancreatic trypsin and chymase.]
Tight junction protein ZO-1	A0A0G2K2P5	[Function: TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and Tjp3, participates to the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity).]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Q64244	[Function: Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.]
Vitamin D 25-hydroxylase	Q6VVW9	[Function: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).]
Origin recognition complex subunit 2	Q75PQ8	[Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity).]
Tripartite motif-containing protein 26	Q99PN3	[Function: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.]
Basic leucine zipper and W2 domain-containing protein 1	Q7L1Q6	[Function: Enhances histone H4 gene transcription but does not seem to bind DNA directly.]
Sodium/iodide cotransporter	Q99PN0	[Function: Mediates iodide uptake in the thyroid gland.]
Alpha-defensin 21	Q8C1P2	[Function: May have microbicidal activities.]
Ly6/PLAUR domain-containing protein 6	Q8BPP5	[Function: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx through nAChRs (PubMed:19403274). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).]
E3 ubiquitin-protein ligase DTX3L	Q8TDB6	[Function: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788).]
Solute carrier family 2, facilitated glucose transporter member 14	Q8TDB8	[Function: Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.]
Zinc finger protein 436	Q8BPP0	[Function: May be involved in transcriptional regulation.]
Glutathione hydrolase 6	Q6PDE7	[Function: Cleaves glutathione conjugates.]
Protein mab-21-like 2	Q8BPP1	[Function: Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning.]
Transmembrane protein 180	Q6PDE8
Integrator complex subunit 1	Q8N201	[Function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).]