Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Transient receptor potential cation channel subfamily V member 6	Q9R186	[Function: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226, PubMed:28878326). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).]
Tetraspanin-1	Q99J59
CD99 antigen	Q8VCN6	[Function: Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.]
Protein unc-13 homolog D	Q9R189	[Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (By similarity).]
Neuronal acetylcholine receptor subunit alpha-6	Q9R0W9	[Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.]
Cystathionine gamma-lyase	Q8VCN5	[Function: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.]
Neurexin-1-beta	P58400	[Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).]
Neurexin-2-beta	P58401	[Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.]
Immediate early response gene 5-like protein	Q99J55
Derlin-1	Q99J56	[Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.]
Striatin-4	P58404	[Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.]
Striatin-3	P58405	[Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).]
Glutathione S-transferase Mu 5	P46439	[Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.]
Nicalin	Q8VCM8	[Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.]
Kazal-type serine protease inhibitor domain-containing protein 1	Q8BJ66	[Function: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly.]
Mediator of RNA polymerase II transcription subunit 20	Q9R0X0	[Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).]
Metastasis-associated protein MTA2	Q9R190	[Function: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.]
Protein FAM98B	Q80VD1	[Function: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation.]
Apoptosis regulator Bcl-2	P10417	[Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).]
R-spondin-4	Q8BJ73	[Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.]