Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Terdecamycin	NCIT_C132142
SH3 Domain-Containing Kinase-Binding Protein 1	NCIT_C132143	[SH3 domain-containing kinase-binding protein 1 (665 aa, ~73 kDa) is encoded by the human SH3KBP1 gene. This protein is involved in the modulation of protein-protein interactions.]
Roxindole Hydrochloride	NCIT_C132144
Methylglutaconyl-CoA Hydratase, Mitochondrial	NCIT_C20950	[Methylglutaconyl-CoA hydratase, mitochondrial (339 aa, ~36 kDa) is encoded by the human AUH gene. This protein is involved in amino acid catabolism.]
Pocapavir	NCIT_C132145
Baculoviral IAP Repeat-Containing Protein 7	NCIT_C20951	[Baculoviral IAP repeat-containing protein 7 (298 aa, ~33 kDa) is encoded by the human BIRC7 gene. This protein plays a role in both signal transduction and the inhibition of apoptosis.]
Malignant Solid Neoplasm	NCIT_C132146	[A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.]
Agitation, CTCAE 5.0	NCIT_C146777	[A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.]
Anxiety, CTCAE 5.0	NCIT_C146778	[A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.]
Autologous TCR-engineered T-cells IMA201	NCIT_C146779	[A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.]
Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells	NCIT_C107160	[Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway.]
Heparan Sulfate Glycosaminoglycan Mimetic Nanopolymer Mouthwash	NCIT_C107161	[A nanopolymer-based mouthwash formulation containing a mimetic of the glycosaminoglycan (GAG) heparan sulfate, with potential anti-mucositic and protective activities. Upon rinsing with the mouthwash, GAGs bind to heparan sulfate binding sites on macromolecules within the extracellular matrix (EMC), which prevents the destruction of the ECM and protects both growth factors and cytokines from being degraded. By replacing the GAGs damaged by chemotherapy and/or radiation, this mouthwash may protect healthy tissue against the cytotoxic effects of chemotherapy and radiation and may prevent against radio-chemotherapy-induced mucositis.]
Photophobia, CTCAE 5.0	NCIT_C146770	[A disorder characterized by fear and avoidance of light.]
Eye Disorders, CTCAE	NCIT_C143167
Distress over Practical Problem with Child Care	NCIT_C107162	[A question about an individual's distress related to their practical problems with child care.]
Insomnia, CTCAE 5.0	NCIT_C146771	[A disorder characterized by difficulty in falling asleep and/or remaining asleep.]
Gallium Ga 68-labeled Affibody ABY-025	NCIT_C107163	[A radioconjugate composed of an optimized affibody conjugated, via its C-terminal cysteine, to maleimide-DOTA, and linked to the radioisotope gallium Ga 68, with potential use as a tracer for human epidermal growth factor receptor type 2 (HER2; ErbB2)-expressing tumors using positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-labeled affibody ABY-025, the affibody targets HER2-expressing tumor cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeting chemotherapeutic agents during PET imaging. The affibody is an optimized antibody mimetic based on a 6.5-kDa 3-helical bundle Z domain derived from the staphylococcal protein A (Z her2:342); the nonbinding surface of the Z domain is reengineered (Z her2:2891) to increase binding affinity for HER2 and to improve tumor imaging. HER2 is overexpressed in many cancer cell types.]
Scalp Pain, CTCAE 5.0	NCIT_C146772	[A disorder characterized by a sensation of marked discomfort in the skin covering the top and the back of the head.]
Skin and Subcutaneous Tissue Disorders, CTCAE	NCIT_C143182
Benzaldehyde Dimethane Sulfonate	NCIT_C107164	[A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, benzaldehyde dimethane sulfonate alkylates DNA, which results in DNA double strand breaks, inhibition of DNA replication, cell cycle arrest and cell death. In addition, this agent is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the active carboxylic acid metabolite benzoic acid dimethane sulfonate (BA), which further contributes to its alkylating activity. Unlike other alkylating agents, benzaldehyde dimethane sulfonate has demonstrated antitumor activity in renal cell carcinoma.]