Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
mRNA Surveillance	NCIT_C29645	[mRNA Surveillance works within elaborate cellular mechanisms to ensure accurate gene expression by assessing suitable mRNA quality for translation and prevents the synthesis of truncated or aberrant proteins. By nonsense-mediated decay, mRNA surveillance facilitates the detection and destruction of mRNAs that contain premature termination codons. Also, by nonstop decay, mRNA surveillance depletes mRNAs that lack in-frame termination codons.]
BCL6 Positive	NCIT_C132011	[An indication that B-cell lymphoma 6 expression has been detected in a sample.]
RNA Proof-Reading	NCIT_C29646	[RNA Proof-Reading is the process whereby RNA polymerase can backup and remove incorrect bases during the process of transcription.]
Transcription Process	NCIT_C28614	[A Transcription Process is any cellular event or activity directly involved in the synthesis a nascent RNA transcript.]
Resectable Head and Neck Squamous Cell Carcinoma	NCIT_C132012	[Squamous cell carcinoma of the head and neck which is amendable to surgical removal.]
Resectable Carcinoma	NCIT_C150604	[Carcinoma that is amenable to surgical resection.]
Head and Neck Squamous Cell Carcinoma	NCIT_C34447	[A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.]
Non-Stop Decay	NCIT_C29647	[In eukaryotes, the non-stop decay mechanism recognizes and degrades mRNAs that lack a stop codon. It releases ribosomes stalled at the 3' end of a mRNA and stimulates the exosome to rapidly degrade the transcript. (from PubMed 12210514)]
TGFbeta Inhibitor LY3200882	NCIT_C132013	[An orally bioavailable agent that targets transforming growth factor-beta (TGFb), with potential antineoplastic activity. Upon administration, LY3200882 specifically targets and binds to TGFb, which prevents both the binding of TGFb to its receptor TGFbR and TGFb-mediated signal transduction. This may lead to a reduction in TGFb-dependent proliferation of cancer cells. The TGFb signaling pathway is often deregulated in tumors, and plays a key role in the regulation of cell growth, differentiation, apoptosis, motility, invasion, angiogenesis, and various immune responses.]
Nonsense-Mediated Decay	NCIT_C29648	[Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs with premature stop codons and mark the transcript for rapid decay. Degrading mRNAs from both ends, NMD involves decapping, deadenylating, and exonucleolytic activities.]
Sustained-Exposure Dexamethasone Formulation OTO-104	NCIT_C132014	[A sustained-release (SR) poloxamer hydrogel formulation containing the glucocorticoid dexamethasone (DXM), with potential otoprotective and anti-apoptotic activities. Prior to the administration of an ototoxic drug and upon intratympanic (IT) injection of the DXM sustained-exposure formulation OTO-104, DXM is slowly released from the hydrogel over time; DMX then binds to glucocorticoid nuclear receptors, and activates cell survival pathways. This prevents ototoxic drug-induced generation of reactive oxygen species (ROS) by activating anti-oxidant enzymes, blocking the activation of inflammatory cytokines and inducing stress signaling pathways, which ultimately prevents apoptosis of auditory hair cells in the inner ear compartment. This prevents or reduces drug-induced ototoxicity caused by certain therapeutic agents, such as platinum-based anticancer agents. This may reduce or prevent hearing loss, tinnitus, and vertigo. The SR formulation provides increased concentrations of DXM in the inner ear and maintains the elevated levels for a longer time without the need of the multiple IT injections needed when using non-SR DXM formulations. This agent also reduces the symptoms of certain ear-related disorders.]
Electrolyte Replacement Preparation	NCIT_C29638	[A mixture containing electrolytes used to prevent or treat electrolyte imbalance that can be caused by abnormal levels of sodium, magnesium, phosphate, chloride, bicarbonate and/or potassium. Severe electrolyte disturbances can cause cardiac and neurological problems, organ failure and eventually death.]
Anti-c-Met Antibody-drug Conjugate HTI-1066	NCIT_C146667	[An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the tumor-associated antigen (TAA) the proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of HTI-1066 targets and binds to c-Met expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the c-Met-expressing cancer cells, through an as of yet unknown mechanism of action. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis.]
TP53 Positive	NCIT_C146668	[An indication that TP53 expression has been detected in a sample.]
Myeloblasts 5 Percent or More of Bone Marrow Nucleated Cells	NCIT_C146669	[A semi-quantitative microscopic finding indicating that 5 percent or more of the nucleated cells in a bone marrow sample are immature mononuclear cells of myeloid origin.]
Immature Myeloid Cells Increased in Bone Marrow	NCIT_C42776	[An increased number of myeloid precursors in the bone marrow.]
Blasts 5 Percent or More of Bone Marrow Nucleated Cells	NCIT_C136411	[A microscopic finding indicating the presence of blasts constituting at least 5% of the nucleated cells in a bone marrow aspirate.]
C-SSRS Already Enrolled Subjects - Controllability of Most Severe Ideation (Prior to Study Entry)	NCIT_C107050	[Columbia-Suicidality Severity Rating Scale Already Enrolled Subjects (C-SSRS Already Enrolled Subjects ) Could/can you stop thinking about killing yourself or wanting to die if you want to? (Prior to Study Entry).]
Carworth Farms	NCIT_C15000
C-SSRS Already Enrolled Subjects - Controllability of Most Severe Ideation (Since Study Start)	NCIT_C107051	[Columbia-Suicidality Severity Rating Scale Already Enrolled Subjects (C-SSRS Already Enrolled Subjects ) Could/can you stop thinking about killing yourself or wanting to die if you want to? (Since Study Start).]